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Smith and Williams' Introduction to the Principles of Drug Design and Action, Third Edition
by:H. John Smith, Hywel Williams
The third edition of this popular textbook provides a thorough introduction to the principles of rational drug design, adopting a "from the bench to the market place" approach.As knowledge of biological systems has expanded and the number of techniques available for exploring and visualising their components has increased, it has become possible to design...
The third edition of this popular textbook provides a thorough introduction to the principles of rational drug design, adopting a "from the bench to the market place" approach.As knowledge of biological systems has expanded and the number of techniques available for exploring and visualising their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionised the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated.The principles of drug design are demonstrated using real examples, illustrating the discovery of "lead" compounds and their manipulation to produce nontoxic drug candidates, which will successfully interact with target receptors in a predicted fashion. In addition to fully up-dating the previous edition, important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, a
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