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Design and Analysis of Clinical Trials: Concepts and Methodologies (Wiley Series in Probability and Statistics)
by:Shein-Chung Chow, Jen-Pei Liu
Praise for the First Edition of Design and Analysis of Clinical Trials"An excellent book, providing a discussion of the clinical trial process from designing the study through analyzing the data, and to regulatory requirement . . . could easily be used as a classroom text to understand the process in the new drug development area."Statistical Methods in...
Praise for the First Edition of Design and Analysis of Clinical Trials"An excellent book, providing a discussion of the clinical trial process from designing the study through analyzing the data, and to regulatory requirement . . . could easily be used as a classroom text to understand the process in the new drug development area."Statistical Methods in MedicineA complete and balanced presentation now revised, updated, and expandedAs the field of research possibilities expands, the need for a working understanding of how to carry out clinical trials only increases. New developments in the theory and practice of clinical research include a growing body of literature on the subject, new technologies and methodologies, and new guidelines from the International Conference on Harmonization (ICH).Design and Analysis of Clinical Trials, Second Edition provides both a comprehensive, unified presentation of principles and methodologies for various clinical trials, and a well-balanced summary of current regulatory requirements. This unique resource bridges the gap between clinical and statistical disciplines, covering both fields in a lucid and accessible manner. Thoroughly updated from its first edition, the Second Edition of Design and Analysis of Clinical Trials features new topics such as:Clinical trials and regulations, especially those of the ICHClinical significance, reproducibility, and generalizabilityGoals of clinical trials and target populationNew study designs and trial typesSample size determination on equivalence and noninferiority trials, as well as comparing variabilitiesAlso, three entirely new chapters cover:Designs for cancer clinical trialsPreparation and implementation of a clinical protocolData management of a clinical trialWritten with the practitioner in mind, the presentation assumes only a minimal mathematical and statistical background for its reader. Instead, the writing emphasizes real-life examples and illustrations from clinical case studies, as well as numerous references-280 of them new to the Second Edition-to the literature. Design and Analysis of Clinical Trials, Second Edition will benefit academic, pharmaceutical, medical, and regulatory scientists/researchers, statisticians, and graduate-level students in these areas by serving as a useful, thorough reference source for clinical research.
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